While it is known that dietary nitrate enhances exercise, both boosting endurance and enhancing high-intensity exercise, researchers still have much to learn about why this effect occurs, and how our bodies convert dietary nitrate that we ingest into the nitric oxide that can be used by our cells. To help close this gap, researchers at the University of Exeter and the U.S. … [Read more...]
Physical Activity can Help Mental Health in Pre-teen Years
Engaging in regular moderate to vigorous physical activity at age 11 was associated with better mental health between the ages of 11 and 13, the study found. Physical activity was also associated with reduced hyperactivity and behavioural problems, such as loss of temper, fighting with other children, lying, and stealing, in young people. Researchers from the Universities … [Read more...]
Assessing the Risk of Excess Folic Acid Intake
"However, there is a lack of research on whether excessive folic acid intake has the potential to harm human beings," said co-corresponding author, Dr. Richard H. Finnell, William T. Butler, M.D., Distinguished Chair Professor in the Center for Precision Environmental Health and the departments of molecular and cellular biology, molecular and human genetics and medicine at … [Read more...]
Study Reveals New Understanding of How Androgen Therapy Affects Breast Tissue
Transgender men who were assigned female at birth and identify today as male may take hormones called androgens to induce physical changes that help them align their physical appearance with their identified gender. Androgens such as testosterone are involved primarily in the development of male traits, although females also produce androgens. Molecular changes observed in … [Read more...]
Adding Antipsychotic Med to Antidepressant May help Older Adults with Treatment-Resistant Depression
Aripiprazole originally was approved by the FDA in 2002 as a treatment for schizophrenia but also has been used in lower doses as an add-on treatment for clinical depression in younger patients who do not respond to antidepressants alone. The new findings are published March 3 in The New England Journal of Medicine and are to be presented that same day by Eric J. Lenze, MD … [Read more...]
Mocktails or Cocktails? Having a Sense of Purpose in Life can Keep Binge Drinking at Bay
Using functional MRI (fMRI) scanning technology, researchers from the University of Pennsylvania, Columbia University, and Dartmouth College examined the relationship between these cues, alcohol craving, and alcohol consumption. They found that having a strong sense of purpose in life decreases the temptation to consume alcohol to excess among some social drinkers. Why … [Read more...]
Will Revitalizing Old Blood Slow Aging?
Many scientists are looking for the elements of young blood that can be captured or replicated and put into a pill. But what if the best way to get the benefits of young blood is to simply rejuvenate the system that makes blood? "An aging blood system, because it's a vector for a lot of proteins, cytokines, and cells, has a lot of bad consequences for the organism," says … [Read more...]
Youth Overweight a Risk Factor for Blood Clots as Adult
The association between obesity and blood clots is already established. However, to date it has been unclear how much influence a raised BMI in childhood and puberty exerts. The purpose of the study was to clarify the links between BMI in early life and subsequent thrombi. Thrombi usually arise in the legs, often starting in a blood vessel in the calf. Swelling, pain and … [Read more...]
Rhythmic Eating Pattern Preserves Fruit Fly Muscle Function Under Obese Conditions
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels. Interestingly, studies in various animal models have shown that … [Read more...]
Effect of Dietary Choline Deficiency on Neurologic and System-Wide Health
It's estimated that more than 90% of Americans are not meeting the recommended daily intake of choline. The current research, conducted in mice, suggests that dietary choline deficiency can have profound negative effects on the heart, liver and other organs. Lack of adequate choline is also linked with profound changes in the brain associated with Alzheimer's disease. These … [Read more...]
Body Dissatisfaction Can Lead to Eating Disorders at Any Age
Body Dissatisfaction Can Lead to Eating Disorders at Any Age ++nutrition Eating disorders are serious mental health conditions characterized by disturbances in eating behavior and body image that occur in approximately 13.1% of women across the lifespan. The prevalence of any eating disorder specifically for women aged older than 40 years is roughly 3.5%, with specific … [Read more...]
Preterm Birth Linked to Chemicals Found in the Vagina, Study Finds
The study of 232 pregnant women found that a handful of non-biological chemicals previously found in cosmetics and hygiene products are strongly associated with preterm birth. "Our findings suggest that we need to look more closely at whether common environmental exposures are in fact causing preterm births and, if so, where these exposures are coming from," says study … [Read more...]
Feeling Depressed? Performing acts of Kindness may help
People suffering from symptoms of depression or anxiety may help heal themselves by doing good deeds for others, new research shows. The study found that performing acts of kindness led to improvements not seen in two other therapeutic techniques used to treat depression or anxiety. Most importantly, the acts of kindness technique was the only intervention tested that … [Read more...]
Consumption of Fast Food Linked to Liver Disease
A study from Keck Medicine of USC published today in Clinical Gastroenterology and Hepatology gives people extra motivation to reduce fast-food consumption. The study found that eating fast food is associated with nonalcoholic fatty liver disease, a potentially life-threatening condition in which fat builds up in the liver. Researchers discovered that people with obesity … [Read more...]
Better Planning, Behavior Regulation can Lead to Eating Less Fat
New research suggests coaching overweight or obese pregnant women to improve their ability to plan and make progress toward goals may be key to helping them lower the amount of fat in their diet. Maternal diet quality affects prenatal development and long-term child health outcomes, but the stress that typically increases during pregnancy -- often heightened by concern for … [Read more...]
Discovery of Metabolic Switch Could Lead to Targeted Treatment of Obesity, Cancer
An Iowa State University research team has discovered a method for modifying the function of an enzyme crucial to fat production, which could lead to more effective treatments for childhood obesity and cancer. While the research was in fruit fly larvae, being able to speed up or slow down lipid metabolism could have significant implications for human health, said Hua Bai, … [Read more...]
Does The Risk of Stroke From Common Risk Factors Change as People age?
"High blood pressure and diabetes are two important risk factors for stroke that can be managed by medication, decreasing a person's risk," said study author George Howard, DrPH, of the University of Alabama at Birmingham School of Public Health. "Our findings show that their association with stroke risk may be substantially less at older ages, yet other risk factors do not … [Read more...]
Study Reveals Obesity-Related Trigger That can Lead to Diabetes
A new study at Washington University School of Medicine in St. Louis may help explain how excess weight can contribute to diabetes and may provide researchers with a target to help prevent or delay diabetes in some of those at risk. The findings suggest that many people with elevated levels of insulin -- an early marker of diabetes risk -- also have defects in an enzyme … [Read more...]
Honey reduces cardiometabolic risks, study shows
The researchers conducted a systematic review and meta-analysis of clinical trials on honey, and found that it lowered fasting blood glucose, total and LDL or 'bad' cholesterol, triglycerides, and a marker of fatty liver disease; it also increased HDL or 'good' cholesterol, and some markers of inflammation. "These results are surprising, because honey is about 80 per cent … [Read more...]
Brain Organoids Reveal in Detail the Harms of Prenatal Alcohol Exposure
The consequences of prenatal alcohol exposure (PAE) are reflected in the different diagnoses that emerge under the umbrella of fetal alcohol spectrum disorders. At one end of the spectrum, growth deficits and physical differences define fetal alcohol syndrome (FAS), but in most cases, irreversible brain damage leads to behavior and learning challenges even without a physical … [Read more...]
Study Compares Adverse Events After Two Types of Bariatric Surgery in Adolescents
Adolescents who underwent sleeve gastrectomy, a type of weight-loss surgery that involves removing part of the stomach, were less likely to go the emergency room or be admitted to the hospital in the five years after their operations than those who had their stomachs divided into pouches through gastric bypass surgery, according to new research. Rates of complications, death … [Read more...]
Dietary Change Starves Cancer Cells, Overcoming Treatment Resistance
Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1. While mTORC1 is known to be … [Read more...]
Exercise can Reduce Severity of Breast Cancer Rreatment Side Effects
Breast cancer is the most common form of the disease among women; in Australia, one in eight women will be diagnosed with breast cancer by the age of 85. Radiotherapy has emerged as an important component of breast cancer treatment but can lead to cancer-related fatigue and negatively impact patients' health-related quality of life including their emotional, physical and … [Read more...]
Black tea (and other favorites) may help your health later in life
A daily cup of tea could help you to enjoy better health late in life -- however if you're not a tea drinker, there are other things you can add to your diet. The key is flavonoids, which are naturally occurring substances found in many common foods and beverages such as black and green tea, apples, nuts, citrus fruit, berries and more. They have long been known to have … [Read more...]
Healthy Aging Requires an Understanding of Personality Yypes
New research shows that older adults may be better supported as they age when their personalities are considered -- for example, are they more like orchids or dandelions? Researchers from Simon Fraser University's Circle Innovation examined the potential effects of lifestyle activities on the cognitive health of more than 3,500 adults aged 60+, and found that … [Read more...]
Which Grains you Eat can Impact Your Risk of Getting Heart Disease Earlier
In one of the first studies to examine the relationship between different types of grain intake and premature coronary artery disease in the Middle East, researchers found a higher intake of refined grain was associated with an increased risk of premature coronary artery disease in an Iranian population, while eating whole grains was associated with reduced risk. The study will … [Read more...]
Combining Time-Restricted Eating and HIIT Improves Health Measures in Women with Obesity
Both time-restricted eating (TRE) and high-intensity interval training (HIIT) have been shown to improve cardiometabolic health in people who are overweight and at risk of serious disease. Now a randomized, controlled trial has tested whether combining these two approaches is more effective than either of them on their own. The results, publishing in the journal Cell Metabolism … [Read more...]
Scientists Chart How Exercise Affects The Body
Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved. In a new study in mice that expands researchers' understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out … [Read more...]
Prenatal Acetaminophen use Linked to Sleep, Attention Problems in Preschoolers
Acetaminophen use during pregnancy is associated with sleep and behavior problems consistent with attention deficit hyperactivity disorder (ADHD), according to a study by Penn State College of Medicine researchers. Acetaminophen is a common drug used to treat a variety of issues, including fever, infection, muscle pain, headache, migraine, colds and allergies. Traditionally, … [Read more...]
Blood Levels of ‘Free Range’ DNA may Signal Early Detection of Dementia and Frailty
In a long-term prospective study of more than 600 older participants, Johns Hopkins Medicine researchers say they have evidence that higher levels of cell-free DNA circulating in the blood may signal increased risk of chronic inflammation associated with early signs of frailty and dementia. The findings, published Oct. 11 in the Journal of Alzheimer's Disease, could advance … [Read more...]
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