The protein normally performs necessary housekeeping in the brain's hippocampus by working as part of a larger protein complex called the proteasome to destroy other proteins. But researchers in the College of Agriculture and Life Sciences' School of Animal Sciences recently noticed this protein, called RPT6, behaving in a previously undetected way. "We found that RPT6 is … [Read more...]
Physical Exercise Boosts Motor Learning and Remembering What one has Learned
Before a violinist tunes their instrument or surgeon stands at the training table to learn the skills needed for a new symphony or surgical procedure, they might consider heading out for a bike ride or run. Once they've practiced the new skill, there's good reason to put on their workout attire again. Indeed, being physically active and elevating one's heart rate has the … [Read more...]
Main Regulator for the Body’s ‘Oven’ Discovered
Obesity is defined as a pathological increase in white fat, and has become a major problem worldwide, with a greatly increased risk of cardiovascular diseases such as heart attack and stroke. "Exercise and dieting are not enough to effectively and permanently shed the pounds," says corresponding author Prof. Alexander Pfeifer, Director of the Institute of Pharmacology and … [Read more...]
Dietary Restriction Slows Brain Aging and Increases lifespan
Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Buck scientists have uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging. "When people restrict the … [Read more...]
Reduced Blood Lead Levels Linked to Lower Blood Pressure
Through the Strong Heart Family Study, National Institutes of Health-supported researchers found that small declines in blood lead levelswere associated with long-term cardiovascular health improvements in American Indian adults. Participants who had the greatest reductions in blood lead levels saw their systolic blood pressure fall by about 7 mm Hg, an amount comparable to the … [Read more...]
Why Cancer Immunotherapies don’t Work for Everyone
Why cancer immunotherapies don't work for everyone (cancer) The study, published in the peer-reviewed journal Cell Reports, sheds light on why immunotherapy treatments don't work for all people or all diseases. For example, certain types of cancers -- including colon, pancreatic, prostate and brain cancers -- have stubbornly resisted immunotherapy. And while breast, … [Read more...]
Artificial Intelligence and Immunity
Researchers from Cleveland Clinic and IBM have published a strategy for identifying new targets for immunotherapy through artificial intelligence (AI). This is the first peer-reviewed publication from the two organizations' Discovery Accelerator partnership, designed to advance research in healthcare and life sciences. The team worked together to develop supervised and … [Read more...]
However, Adults Hardly have any Brown Fat, and it can be Found Mainly in Young and Slim People.
"We therefore asked how brown fat mass can be increased while simultaneously reducing bad white fat," says Bonn postdoctoral researcher and first author Dr. Laia Reverte-Salisa. Together with researchers from the University Medical Center Hamburg-Eppendorf, Helmholtz Munich and the University of Toulouse-Paul Sabatier, the Bonn team investigated the cAMP signaling pathway in … [Read more...]
Different Pain Types in Multiple Sclerosis can Cause Difficulty Ataying Active
For patients with multiple sclerosis, a regular exercise routine is important for managing symptoms. Due to different causes of chronic pain though, physical exercise can be more difficult for some. Research published in the Journal of Pain from the University of Michigan found that widespread pain with nociplastic features, also known as WPNF, can make engaging in physical … [Read more...]
Main Regulator for the Body`s ‘oven’ Discovered
Brown fat cells convert energy into heat -- a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area "Life & Health" at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown … [Read more...]
Algae as a Surprising Meat Alternative and Source of Environmentally Friendly Protein
With more of us looking for alternatives to eating animals, new research has found a surprising environmentally friendly source of protein -- algae. The University of Exeter study has been published in The Journal of Nutrition and is the first of its kind to demonstrate that the ingestion of two of the most commercially available algal species are rich in protein which … [Read more...]
Survey Participants Who were Controlling Their Type 2 Diabetes ate Fewer Sugary Foods and Snacked Less Overall than Participants Without Diabetes and Those Whose Blood Sugar Levels Indicated They Were Prediabetic.
"Diabetes education looks like it's working, but we might need to bump education back to people who are at risk for diabetes and even to people with normal blood glucose levels to start improving dietary behaviors before people develop chronic disease," Taylor said. The study was published recently in PLOS Global Public Health. Researchers analyzed data from 23,708 U.S. … [Read more...]
Participants in School-Based Gardening and Food Programs Benefit From Lasting Impacts on Dietary Behaviors
To encourage fruit and vegetable consumption among youth, experiential food education programs such as gardening and cooking lessons have increased across both community and school settings. A recent research article in the Journal of Nutrition Education and Behavior, published by Elsevier, revealed how this early learning positively influenced food decisions as children grew … [Read more...]
US Adults Eat a Meal’s Worth of Calories of Snacks in a Day
Snacks constitute almost a quarter of a day's calories in U.S. adults and account for about one-third of daily added sugar, a new study suggests. Researchers analyzing data from surveys of over 20,000 people found that Americans averaged about 400 to 500 calories in snacks a day - often more than what they consumed at breakfast - that offered little nutritional … [Read more...]
Study Charts Possibilities for a Better way to Diagnose Gestational Diabetes
Pregnancy weight and biochemical markers measured in blood from women with gestational diabetes mellitus (GDM) were related to increased risk of poor pregnancy outcomes, suggesting a new direction for precision diagnostics, according to researchers. The study led by Ellen C. Francis, an assistant professor in the Department of Biostatistics and Epidemiology at Rutgers School … [Read more...]
Epigenetic Therapy Shows Promise for Endocrine-Resistant Breast Cancer
Using a low dose of the epigenetic therapy drug decitabine, which is currently used to treat some blood cancers, the researchers significantly suppressed the growth of endocrine-resistant breast tumours in mice and increased survival time by 90%. The finding, which will be tested in a future Phase I clinical trial, is a potential gamechanger for the more than 4,000 people who … [Read more...]
Study Unveils a Role of Mitochondria in Dietary Fat Processing
The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods contributes to metabolic diseases such as obesity and atherosclerosis, fat is an indispensable component of our diet. Digested lipids supply the body with essential building blocks and facilitate the absorption of important vitamins. In a new study … [Read more...]
Large-Scale Study Uncovers Modifiable Risk Factors For Young-Onset Dementia
Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies. The largescale study identified 15 risk factors, which are similar to those for late-onset dementia. For the first time, they indicate that it may be … [Read more...]
Study: Cuddling During Sleep Comes at a Cost, Even for Mice
If you’re having trouble sleeping, perhaps contact with a bedmate is causing the problem, say University of Michigan researchers. Ada Eban-Rothschild, assistant professor in U-M’s Department of Psychology, and colleagues tracked the sleep behavior of mice while in a social context. They noticed that these small rodents seek physical contact prior to sleep initiation and … [Read more...]
Elevated Pregnancy Blood Pressure may Leave Lasting Marks on the Heart
New research from the Smidt Heart Institute at Cedars-Sinai found that women who developed signs of elevated blood pressure during pregnancy were more likely to have residual evidence of abnormal heart structure and function up to a decade after the pregnancy. "This study helps to clarify that, for some women, pregnancy is not just a 'stress test' that unmasks underlying … [Read more...]
Dietary Shifts to Less Processed Foods Significantly Lower Triglycerides in Women
During reproductive age, poor nutrition quality increases obesity rates and, as a result, the risk of cardiovascular disease (CVD) and type 2 diabetes. Dyslipidemia also impacts health, particularly among women with polycystic ovary syndrome (PCOS). In pregnant women, elevated triglycerides increase the risk of gestational diabetes, which can lead to type 2 diabetes and CVD … [Read more...]
How Pre- and Postnatal B-12 Vitamins Improve Breast Milk Which Supports Infant Brain Development
Babies and children need vitamins, including vitamin B-12, to help their brains and bodies develop and grow. Babies get B-12 from their mothers and can have low levels of B-12 if their mothers had low vitamin levels during pregnancy and breastfeeding. The vitamin B-12 levels of infants strongly depend on maternal levels. Adequacy of vitamin B-12 in breast milk is particularly … [Read more...]
People With Obesity Burn Less Energy During Day
Weight influences how and when bodies burn energy, new research indicates. An Oregon Health & Science University study published in the journal Obesity found people who have a healthy weight use more energy during the day, when most people are active and eat, while those who have obesity spend more energy during the night, when most people sleep. The study also found … [Read more...]
Benefits of Adolescent Fitness to Future Cardiovascular Health Possibly Overestimated
There is a well-known relationship between good physical fitness at a young age and a lower risk of cardiovascular disease later in life. However, when researchers adjusted for familial factors by means of sibling analysis, they found a weaker association, although the link between high body mass index (BMI) and cardiovascular disease remained strong. The study, which was … [Read more...]
Fat Cells Help Repair Damaged Nerves
Damage to the body's peripheral nerves can cause pain and movement disorders. Researchers at the Leipzig University have recently investigated how damaged nerves can regenerate better. They found that fat tissue strongly supports the Schwann cells needed for repair during the healing process. The results were published in the journal Cell Metabolism. Our bodies are … [Read more...]
Are Healthy Foods Automatically Sustainable, Too?
Many people are keen on making healthy as well as sustainable food choices, and they often intuitively equate "healthy" with being "sustainable." A study by researchers at the University of Konstanz, the Johannes Kepler University Linz and the Hamburg University of Applied Sciences is focusing on whether or not this perception corresponds to reality. It has just been published … [Read more...]
Measuring Long-Term Heart Stress Dynamics with Smartwatch Data
Biomedical engineers at Duke University have developed a method using data from wearable devices such as smartwatches to digitally mimic an entire week's worth of an individual's heartbeats. The previous record covered only a few minutes. Called the Longitudinal Hemodynamic Mapping Framework (LHMF), the approach creates "digital twins" of a specific patient's blood flow to … [Read more...]
New Research Links High Salt Consumption to Risk of Type 2 Diabetes
Those at risk for Type 2 diabetes may already know to avoid sugar, but new research suggests they may want to skip the salt as well. A new study from Tulane University published in Mayo Clinic Proceedings found that frequently adding salt to foods was associated with an increased risk of developing Type 2 diabetes. The study surveyed more than 400,000 adults registered in … [Read more...]
Shortening Sleep Time Increases Diabetes Risk in Women
A new study at Columbia University has found that shortening sleep by just 90 minutes for six weeks increased insulin resistance in women who are accustomed to getting adequate sleep. The effect was even more pronounced in postmenopausal women. The recommended amount of sleep for optimal health is between seven and nine hours per night, yet about one-third of Americans get … [Read more...]
Hope For Autoimmune Skin Disorder Sufferers With New Immunotherapy Strategy
Researchers, led by University of Melbourne's Professor Laura Mackay, a Laboratory Head and Immunology Theme Leader at the Peter Doherty Institute of Infection and Immunity (Doherty Institute), discovered distinct mechanisms controlling different types of immune cells, and found that, by precisely targeting these mechanisms, they could selectively eliminate 'problematic cells' … [Read more...]
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