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Top 10 Worst and Dangerous Incurable Diseases in the world
 Lesch–Nyhan syndrome
 This
is an inherited disorder which is caused by the deficiency of a certain enzyme,
causing a build-up of uric acid in the body fluids. This leads to poor muscle
control and mental retardation. Sufferers often self-mutilate and can be
violent. Although there’s no cure, sufferers do often live to adulthood.
Lesch–Nyhan syndrome (LNS), also known as Nyhan's syndrome, Kelley-Seegmiller
syndrome and juvenile gout, is a rare inherited disorder caused by a deficiency
of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), produced
by mutations in the HPRT gene located on (the) X chromosome. LNS affects about
one in 380,000 live births. The disorder was first recognized and clinically
characterized by medical student Michael Lesch and his mentor, pediatrician
William Nyhan, who published their findings in 1964.
The HGPRT deficiency causes a build-up of uric acid in all body fluids. This
results in both hyperuricemia and hyperuricosuria, associated with severe gout
and kidney problems. Neurological signs include poor muscle control and moderate
mental retardation. These complications usually appear in the first year of
life. Beginning in the second year of life, a particularly striking feature of
LNS is self-mutilating behaviors, characterized by lip and finger biting.
Neurological symptoms include facial grimacing, involuntary writhing, and
repetitive movements of the arms and legs similar to those seen in Huntington's
disease. The etiology of the neurological abnormalities remains unknown. Because
a lack of HGPRT causes the body to poorly utilize vitamin B12, some boys may
develop megaloblastic anemia.
LNS is an X-linked recessive disease: the gene mutation is usually carried by
the mother and passed on to her son, although one-third of all cases arise de
novo (from new mutations) and do not have a family history. LNS is present at
birth in baby boys. Most, but not all, persons with this deficiency have severe
mental and physical problems throughout life. There are a few rare cases in the
world of affected females.
The symptoms caused by the buildup of uric acid (gout and renal symptoms)
respond well to treatment with drugs such as allopurinol that reduce the levels
of uric acid in the blood. The mental deficits and self-mutilating behavior do
not respond well to treatment. There is no cure, but many patients live to
adulthood. Several new experimental treatments may alleviate symptoms.
LNS is characterized by three major hallmarks: neurologic dysfunction, cognitive
and behavioral disturbances including self-mutilation, and uric acid
overproduction (hyperuricemia). Damage to the basal ganglia causes sufferers to
adopt a characteristic fencing stance due to the nature of the lesion. Some may
also be afflicted with macrocytic anemia. Virtually all patients are male; males
suffer delayed growth and puberty, and most develop shrunken testicles or
testicular atrophy. Female carriers are at an increased risk for gouty arthritis
but are usually otherwise unaffected.
Overproduction of uric acid
One of the first symptoms of the disease is the presence of sand-like crystals
of uric acid in the diapers of the affected infant. Overproduction of uric acid
may lead to the development of uric acid crystals or stones in the kidneys,
ureters, or bladder. Such crystals deposited in joints later in the disease may
produce gout-like arthritis, with swelling and tenderness.
The overproduction of uric acid is present at birth, but may not be recognized
by routine clinical laboratory testing methods. The serum uric acid
concentration is often normal, as the excess purines are promptly eliminated in
the urine. The crystals usually appear as an orange grainy material, or they may
coalesce to form either multiple tiny stones or distinct large stones that are
difficult to pass. The stones, or calculi, usually cause hematuria (blood in the
urine) and increase the risk of urinary tract infection. Some victims suffer
kidney damage due to such kidney stones. Stones may be the presenting feature of
the disease, but can go undetected for months or even years.
Nervous system impairment
The periods before and surrounding birth are typically normal in individuals
with LNS. The most common presenting features are abnormally decreased muscle
tone (hypotonia) and developmental delay, which are evident by three to six
months of age. Affected individuals are late in sitting up, while most never
crawl or walk. Lack of speech is also a very common trait associated with LNS.
Irritability is most often noticed along with the first signs of nervous system
impairment. Within the first few years of life, extrapyramidal involvement
causes abnormal involuntary muscle contractions such as loss of motor control (dystonia),
writhing motions (choreoathetosis), and arching of the spine (opisthotonus).
Signs of pyramidal system involvement, including spasticity, overactive reflexes
(hyperreflexia) and extensor plantar reflexes, also occur. The resemblance to
athetoid cerebral palsy is apparent in the neurologic aspects of LNS. As a
result, most individuals are initially diagnosed as having cerebral palsy. The
motor disability is so extensive that most individuals never walk, and become
lifelong wheelchair users.
Self-injuring behavior
 Persons affected are cognitively impaired and have behavioral disturbances that
emerge between two and three years of age. The uncontrollable self-injury
associated with LNS also usually begins at three years of age. The self-injury
begins with biting of the lips and tongue; as the disease progresses, affected
individuals frequently develop finger biting and head banging. The self-injury
can increase during times of stress. Self-harm is a distinguishing
characteristic of the disease and is apparent in 85% of affected males.
The majority of individuals are cognitively impaired, which is sometimes
difficult to distinguish from other symptoms because of the behavioral
disturbances and motor deficits associated with the syndrome. In many ways, the
behaviors may be seen as a psychological extension of the compulsion to cause
self-injury, and include rejecting desired treats or travel, repaying kindness
with coldness or rage, failing to answer test questions correctly despite study
and a desire to succeed, provoking anger from caregivers when affection is
desired.
Compulsive behaviors also occur, including aggressiveness, vomiting, spitting,
and coprolalia (involuntary swearing). The development of this type of behavior
is sometimes seen within the first year, or in early childhood, but others may
not develop it until later in life.
LNS in females
While carrier females are generally an asymptomatic condition, they do
experience an increase in uric acid excretion, and some may develop symptoms of
hyperuricemia, and suffer from gout in their later years. Testing in this
context has no clinical consequence, but it may reveal the possibility of
transmitting the trait to male children. Women may also require testing if a
male child develops LNS. In this instance, a negative test means the son's
disease is the result of a new mutation, and the risk in siblings is not
increased.
Females who carry one copy of the defective gene are carriers with a 50% chance
of passing the disease on to their sons. In order for a female to be affected,
she would need to have two copies of the mutated gene, one of which would be
inherited from her father. Males affected with LNS do not usually have children
due to the debilitating effects of the disease. It is possible for a female to
inherit an X chromosome from her unaffected father, who carries a new mutation
of the HGPRT gene. Under these circumstances, a girl could be born with LNS, and
though there are a few reports of this happening, it is very rare. The
overwhelming majority of patients with LNS are male.
Less severe forms
A less severe related disease is partial HPRT deficiency is known as
Kelley-Seegmiller Syndrome (Lesch-Nyhan Syndrome involves total HPRT
deficiency). Symptoms generally involve less neurological involvement but the
disease still causes gout and kidney stones.
Diagnosis
When an affected individual has fully developed the three clinical elements of
uric acid overproduction, neurologic dysfunction, and cognitive and behavioral
disturbances, diagnosis of LNS is easily made. Diagnosis is less easy in the
early stages, when the three features are not yet obvious. Suspicion often comes
about when the developmental delay of the individual is associated with
hyperuricemia. Otherwise, the diagnosis should be alleged when developmental
delay is associated with kidney stones (nephrolithiasis) or blood in the urine
(hematuria), caused by uric acid stones. For the most part, Lesch–Nyhan syndrome
is first suspected when self-inflicted injury behavior develops. However,
self-injurious behaviors occur in other conditions, including nonspecific mental
retardation, autism, Rett syndrome, Cornelia de Lange syndrome, Tourette
syndrome, familial dysautonomia, choreoacanthocytosis, sensory neuropathy
including hereditary sensory neuropathy type 1, and several psychiatric
conditions. Of these, only individuals with Lesch–Nyhan syndrome, de Lange
syndrome, and familial dysautonomia recurrently display loss of tissue as a
consequence. Biting the fingers and lips is a definitive feature of Lesch–Nyhan
syndrome; in other syndromes associated with self-injury, the behaviors usually
consist of head banging and nonspecific self-mutilation, but not biting of the
cheeks, lips and fingers. Lesch–Nyhan syndrome ought to be clearly considered
only when self-injurious behavior takes place in conjunction with hyperuricemia
and neurological dysfunction.
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Dated 19 October 2013
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