Breast Cancer Risk Factors Differ Among Ethnic Groups
Reported April 28, 2010
(Ivanhoe Newswire) — Breast cancer occurs more frequently in certain ethnic and racial groups, but the reasons behind these differences are not fully understood. For example, factors known to increase the risk of breast cancer among white women have less influence in Hispanic women.
Lisa Hines, ScD, of the University of Colorado at Colorado Springs, and colleagues conducted a study that considered how established breast cancer risk factorsincluding reproductive history, family history of breast cancer, menstrual history, hormone use, alcohol consumption, physical activity, height, and body mass indexmight be involved in explaining some of the observed differences in the occurrence of breast cancer among racial and ethnic groups. They studied breast cancer among women from the Southwest United States who were enrolled in the population-based, case-control 4-Corners Breast Cancer Study, which investigated factors that contribute to the difference in breast cancer incidence rates observed between Hispanic and non-Hispanic white women.
In this study, the researchers found that 62 to 75 percent of breast cancer cases among non-Hispanic white women were attributed to known breast cancer risk factors, compared with only 7 to 36 percent of cases among Hispanic women. Hispanic women were more likely to have characteristics associated with lower breast cancer risk, such as earlier age at first childbirth, having more children, shorter height, less hormone use, and less alcohol consumption.
Among premenopausal women, taller height and family history of breast cancer were associated with increased risk in non-Hispanic white women, but not among Hispanic women. Among postmenopausal women, certain breast cancer risk factors in non-Hispanic whites, such as recent hormone therapy use and younger age at menarche, had little or no associations with breast cancer in Hispanics.
These findings suggest that many of the risk factors studied to date explain fewer of the breast cancer cases that arise in Hispanic women. “These differences are likely to contribute to disparities in breast cancer incidence rates, and could potentially reflect differences in breast cancer development among these ethnic groups,” Dr. Hines was quoted as saying. For example, ethnic differences in genetic and environmental or lifestyle factors may affect individuals’ susceptibility to the development of breast cancer.
SOURCE: Cancer, online, April 26, 2010