American Mandrake is medicinal and edible (fruit), used extensively by Native Americans. The fully ripe fruit is eaten raw, cooked or made into jams, jellies, marmalades, pies. It is very aromatic, and has a sweet peculiar but agreeable flavor. The seeds and rind are not edible, said to be poisonous. The root and plant contain valuable constituents Quercetin, Kaempferol, Podophyllin, Isorhamnetin, Gallic-acid, Berberine, Alpha-peltatin, that are being studied for their healing, anticancer and other properties. The root is used as a medicinal herb, it is antibilious, cathartic, cytostatic, hydrogogue and purgative, it should only be used by professional Herbalists. It is a most powerful and useful alternative medicine. A possible treatment for cancer is being tested as it contains podophyllin, which has an antimiotic effect (it interferes with cell division and can thus prevent the growth of cells). The resin, which is obtained from the root, is used in the treatment of warts. The whole plant, apart from the ripe fruit, is highly poisonousin large doses. American Mandrake herb produces nausea and vomiting, and even inflammation of the stomach and intestines, which has been known to prove fatal.In moderate doses, it is a drastic purgative with some cholagogue action. Not a medicinal herb to be used during pregnancy, may cause birth defects.