Crila or Crinum latifolium is a herb that arises from an underground bulb. The flowering stems are stout, reaching about 2 m in height. The leaves are long, linear and ligulate. The flowers are white and arranged in an umbel It grows naturally in Asia, from India and Sri Lanka through much of mainland Southeast Asia to south China (Guangxi, Guizhou, Yunnan). In Traditional Medicine, it has been used for urinary and gynecological conditions. Uterus fibroma is effective in treatment by the CRILA capsule. Treatment with Crila® capsule has shown an improvement in menorrhagia/ hypermenorrhea caused due to ULs (uterine leiomyoma).
Scientists have identified 16 alkaloids from Crinum latifolium L Chemical composition of Crinum latifolium L includes glucanes, organic acids, saponin, aminoacids and alkaloids. Glucanes includes glucanes A and B. Aminoacids includes phenyllalamine, L-leucine, DL-valine, L-arginine monohydrocloride. Based on chemical structure, alkaloids from Crinum latifolium L are classified into two groups:
– Non- heterocyclic alkaloids such as latisoline and latisodine
– Heterocyclic alkaloids such as ambeline, paratorimine, pratosine, beladine
In 1984, Ghozal et al. (India) extracted latisoline, a glucoalkaloid in the limb of Crinum latifolium L. An aglycon, lanasodine was also extracted when hydrolyzing parts of Crinum latifolium L. Furthermore, Ghozal and Shipnath have extracted pratorimine and pratosine, two new alkaloids along with Ambeline and Lycorine , two known substances from the bubble of flowering Crinum latifolium L.