(Ivanhoe Newswire) -- We all know exercise is good for us, but
finding the time to do it can be a challenge. If only we could pop a pill
instead...
Thanks to new research out of the Salk Institute, hope is on the horizon. In
studies conducted in mice, investigators there not only discovered a
substance that increased exercise endurance among mice that were exercised
daily, but also one that lead to greater endurance even without the daily
exertion.
“It’s tricking the muscle into ‘believing’ it’s been exercised daily,” study
author Ronald Evans was quoted as saying. “It’s basically the couch potato
experiment, and it proves you can have a pharmacologic equivalent to
exercise.”
Both of the substances are currently available. GW1516, which proved
beneficial in increasing exercise endurance in mice that exercised, is an
experimental drug being tested for the treatment of metabolic disease.
Overall, mice who received the drug along with four weeks of exercise
training increased their running time by 68 percent when compared to similar
mice who trained but received a placebo instead of the active drug. Running
distance went up by 70 percent.
A chemical called AICAR was responsible for the boost in endurance seen in
mice who didn’t exercise. Those mice saw a 44 percent increase in running
endurance.
The researchers believe these drugs might have a role to play in muscle
wasting diseases, or in frail elderly people. They might also help obese
people slim down. However, the authors also note the potential for abuse
among elite athletes who want to boost their exercise endurance, and are
working with the World Anti-Doping Agency to help to keep that from
happening.
SOURCE: Cell, published online July 31, 2008