(HealthDay News) -- A new Canadian study may finally explain how a key compound
found in the U.S.-banned insecticide DDT accelerates the growth of breast cancer
tumors.
The new report, published in the open access journal Breast Cancer Research,
suggests that DDT's main metabolite blocks a pathway of a hormone that would
otherwise help inhibit growth in normally responsive breast cancer cells.
In their study, researchers from Universite Laval and Institut national de santé
publique in Quebec found that the metabolite blocked the androgen receptors (AR)
found on certain human breast cancer cells.
When added to cancer cells having AR, potent androgen compounds slow the tumor's
growth. But the researchers found that when increasing concentrations of the
metabolite were added, the androgen-mediated effects were blocked. The growth of
breast cancer cells known as CAMA-1 actually accelerated, even when androgen was
present to try to mitigate the presence of the hormone estrogen, which normally
signals the cancer cells to grow.
"Our results suggest that in addition to estrogenic compounds, which have been
the main focus of researchers over the past decades, chemicals that block the AR
could favor breast cancer progression," lead researcher Pierre Ayotte said in a
prepared statement.
DDT, a widely used insecticide in the United States from World War II through
the 1970s, has been linked to breast cancer in previous studies. It was banned
stateside following concerns about its affects on wildlife, the environment and
human health, but it is still used in some other countries.
