New Hope for Gout Sufferers
Reported November 14, 2005
(Ivanhoe Newswire) -- Gout is caused from high levels of serum uric acid in the
bloodstream and affects more than 5 million Americans. Until recently, the only
treatment for gout, allopurinol (Zyloprim), was associated with less than
average results. But a recent study shows a new drug is superior in combating
the problem.
Gout is a aching and often disabling form of arthritis with symptoms including
intense attacks of painful swelling in single joints. Commonly it affects the
feet and specifically the big toe. It can result in anything from a day in bed
to having to use crutches indefinitely. It regularly affects men but incidences
increase in women after menopause.
The study, by Robert Wortmann, M.D., of the University of Oklahoma in Norman,
compared the impact of multiple dosage levels of a new drug, febuxostat, to
allopurinol.
In every level, participants taking febuxostat experienced significantly lower
levels of uric acid in their bloodstream compared to participants taking
allopurinol. On average febuxostat lowered 60 percent of the participants' uric
acid levels below 6.8 milligrams per deciliters, the point at which gout arises,
where allopurinol only lowered 22 percent of the participants' levels to the
same degree.
Dr. Wortmann says, "This study is very encouraging because it shows that
febuxostat was superior at lowering serum uric acid levels compared to
allopurinol." For the past 40 years, allopurinol has been the only drug to treat
gout, but with this discovery, researchers are hoping millions of Americans will
find new relief.
SOURCE: American College of Rheumatology, published online Nov. 11, 2005
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